Shah Lab UCSF

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The Shah Lab remains at the forefront of research and innovation focused on enhancing treatment results for patients with chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and other types of cancer. Our ongoing research efforts concentrate on:

• Identifying vulnerabilities and mechanisms of resistance to allosteric kinase inhibitors

• Dissecting molecular mechanisms of kinase activation

• Identifying and overriding on-target and off-target mechanisms of resistance to targeted therapeutics directed against targets such as FLT3, KIT, and mutant IDH

• Identifying mechanisms and mediators of oncogene addition

• Identifying the mechanisms of action of chromatin modifier inhibitors